ASP 2905 ( ASP2905;ASP-2905 )

Catalog No. M15973 CAS No. 792184-90-8

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Datasheet

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HPLC

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Product Name

ASP 2905
Note

Research use only, not for human use.
Brief Description

A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.
Description

A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats.Alzheimer Disease Phase 1 Discontinued
Synonyms

ASP2905;ASP-2905
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

Neurological Disease
Indication

Alzheimer Disease

CAS Number

792184-90-8
Formula Weight

388.41
Molecular Formula

C20H17FN8
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(C=C1)=CC=C1NC2=NC(NC3=CC=CC=C3)=NC(NCC4=NC=CC=N4)=N2.Cl
Chemical Name

N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35.

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